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NEW: Human VEGF ELISA - high sensitivity
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VEGF is considered a key factor in acute lung injury and acute respiratory distress syndrome. Hypoxia and severe inflammation increase the levels of VEGF, significantly elevated in COVID-19 patients. Hypoxic upregulation of VEGF is normally countered by upregulation of ACE2. As SARS-CoV-2 downregulates ACE2, the VEGF-antagonizing effect is cancelled, increasing vascular permeability and aggravating endothelial [...]

Acute declines in kidney #function occur in approximately 20%-30% of patients with acute decompensated  heart failure, but its significance is unclear, and the importance of its context is not known.  In a study by McCallum et al., a decline in estimated glomerular filtration rate (eGFR), related to worsening kidney function, was not significantly associated with [...]

Rafiou Agoro, Pu Ni, Megan L. Noonan, and Kenneth E. White. Front Endocrinol (Lausanne). 2020; 11: 592. Full publication https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7485387/ FGF23 is a phosphaturic hormone derived and secreted primarily by bone osteocytes. Mature, bioactive FGF23 is physiologically designed to target the kidney to regulate phosphate and vitamin D homeostasis; and, in a feedback mechanism to control [...]