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Extracellular vesicles (EVs) are cell-derived membranous structures that contain lipids, proteins, and nucleic acids of the source cell. They are released into the extracellular space and act as intercellular communicators. Receptor activator of NF-κB ligand RANKLL) and its receptor RANK are bone-cell derived key proteins that are crucial in regulating bone remodeling. EVs containing RANKL [...]

Acute kidney injury (AKI) is an abrupt loss of kidney function and is independently associated with high mortality in critically ill patients. Endostatin, the C-terminal proteolytic fragment of collagen XVIII, is expressed during the progression of renal fibrosis. A team of researchers recently demonstrated that serial measurement of plasma endostatin has useful predictive value for [...]

Osteoporosis is the most common bone disease and its prevalence increases with age affecting approximately 200 million people worldwide. Most osteoporosis therapies aim at inhibiting bone resorption, while only a few are capable of actively promoting the generation of new bone tissue. Osteoporosis treatment with anti-Sclerostin antibodies is an newer osteo-anabolic therapy that stimulates bone [...]