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CNP mainly operates through autocrine and paracrine mechanisms and is crucial for promoting bone growth (1). Recent studies have deepened our understanding of CNP's role in cardiovascular regulation (2). It exhibits antifibrotic effects across various organs (3), induces vasodilation in microcirculations, improves myocardial relaxation, and has anti-inflammatory properties (4). These benefits have shown therapeutic potential [...]

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Currently, kidney transplantation (KT) is the optimal treatment option for patients with end-stage kidney disease (ESKD), providing improved survival rates, enhanced quality of life, and greater cost-effectiveness compared to all forms of dialysis (1). However, despite successful transplantation, kidney transplant recipients (KTR) still remain susceptible to graft failure, especially in the long-term period (2). Tubular [...]