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A recent study published in Nature Communications demonstrates that Dickkopf-1 (DKK-1) has a broader role in breast cancer that extends beyond its function as a bone-related biomarker. The publication “Stroma-derived Dickkopf-1 contributes to the suppression of NK cell cytotoxicity in breast cancer,” reports that DKK-1 produced by the tumor stroma can suppress natural killer (NK) [...]

Breast Cancer Awareness Month -  OPG and RANKL Research October marks Breast Cancer Awareness Month, a time to raise awareness and highlight scientific advances that deepen our understanding of breast cancer progression. Although early detection and treatment remain central to improving outcomes, ongoing research continues to uncover the biological pathways that influence how breast cancer [...]

Leucine-rich alpha-2-glycoprotein  (LRG or also used as a synonym LRG1) is a matricellular protein that has been recognized for its role in inflammation, fibrosis, and cardiovascular disease (1). In renal disease, inflammation and vascular complications are key drivers of progression and poor outcomes. For patients with end-stage renal disease undergoing maintenance hemodialysis, traditional risk factors [...]