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Worldwide, cardiovascular diseases (CVDs) are the primary cause of mortality (1). They involve a variety of underlying mechanisms, with increased oxidative stress being one of the key contributing factors. Behavioral risk factors like poor diet, lack of physical activity, and tobacco use are connected to CVDs. Conditions that heighten the risk include obesity, high blood [...]

NT-proBNP at Dialysis Initiation-Predictor of Heart Disease Hospitalization: Patients with end-stage kidney disease (ESKD) face a cardiovascular (CV) death risk approximately 10 to 20 times higher than that of the general population. Cardiac biomarkers serve as a valuable tool to predict CV morbidity and mortality in asymptomatic individuals. About NT-proBNP N-terminal pro-BNP (NT-proBNP) is a [...]

Big Endothelin-1 (Big ET-1) is the precursor to the most potent vasoconstrictor peptide Endothelin-1 (ET-1), which is mainly produced by endothelial cells (1). Interestingly, there is evidence of stimulated ET-1 release from various immune cells, including macrophages and dendritic cells, indicating that these cells can also synthesize ET-1 (2). While ET-1 is essential in regulating [...]