Download biomedica product listMajor depressive disorder and bipolar disorder are accompanied by higher loads of Gram-negative bacteria. This is associated with the invasion of gut bacteria into extraintestinal sites, such as the mesenteric lymph node complex, liver, spleen, kidney, and bloodstream (leaky gut). In response, oxidative stress pathways and #autoimmune responses to oxidative specific epitopes are activated in mood disorders.
If replicated, drugs that protect the integrity of the gut barrier may offer novel therapeutic opportunities for bipolar disorder and major depressive disorder.
Simeonova D, Stoyanov D, Leunis JC, et al. Increased Serum Immunoglobulin Responses to Gut Commensal Gram-Negative Bacteria in Unipolar Major Depression and Bipolar Disorder Type 1, Especially When Melancholia Is Present. Neurotox Res. 2020;37(2):338-348.
Oxidative stress was measured with the Biomedica oxidized LDL (oxLDL) ELISA
• High specificity to MDA adducts
• Small sample volume – 20 µl / well
• Direct measurement
Also check out our oLAB (Anti-Oxidized LDL Autoantibodies) ELISA
• CE marked – for IVD use in the EU
• Only 2 h 15 min total incubation time
• 2 controls included