Infertility is a frequent problem affecting up to 26% of all couples globally. Impaired semen quality is often the cause, but few treatment options exist. The RANKL system is an essential regulator of bone resorption. This current study by Blomberg Jensen M. and colleagues provides insights into a yet unrecognized regulatory role of RANKL in male reproductive function. These findings may ultimately be of clinical relevance since an approved specific RANKL inhibitor is in use to treat osteoporosis in women and men. Read more: https://buff.ly/3tV49aF
Biomedica ELISA kits were used in this study to measure soluble RANKL and OPG in serum and seminal fluid.
ELISA kit highlights:
• CE marked – widely cited in clinical studies
• Reliable – validated according to international guidelines
• High sensitivity – measurable concentrations in healthy subjects
• HIGH quality guaranteed https://buff.ly/3etWGHH
Vascular Endothelial Growth Factor (VEGF) induces angiogenesis, but also disrupts vascular barrier function in diseased tissues. VEGF-mediated pathogenic effects are due to its effects on vascular permeability, resulting in injury to ischemic tissues after stroke or myocardial infarction. In cancer, VEGF-mediated disruption of the vascular barrier may lead to metastatic disease.
Check out our new high quality human VEGF ELISA – developed and manufactured by Biomedica:
Highlights:
√ SMALL SAMPLE VOLUME: only 10µl sample / well required
√ HIGH SENSITIVITY: measurable values in both serum and plasma
√ RELIABLE: rigorously validated according to FDA/ICH/EMEA guidelines
√ EASY: ready to use calibrators & controls included
√ EXCELLENT: correlates with existing methods
√ DAY TEST: results in 4.5 h
Literature:
Review: VEGF in Signaling and Disease: Beyond Discovery and Development. Apte RS et al., Cell. 2019; 176, 6: 1248–64.
e-Poster: “Highly sensitive quantification of human VEGF with an ELISA”
Major depressive disorder and bipolar disorder are accompanied by higher loads of Gram-negative bacteria. This is associated with the invasion of gut bacteria into extraintestinal sites, such as the mesenteric lymph node complex, liver, spleen, kidney, and bloodstream (leaky gut). In response, oxidative stress pathways and #autoimmune responses to oxidative specific epitopes are activated in mood disorders.
If replicated, drugs that protect the integrity of the gut barrier may offer novel therapeutic opportunities for bipolar disorder and major depressive disorder.
Simeonova D, Stoyanov D, Leunis JC, et al. Increased Serum Immunoglobulin Responses to Gut Commensal Gram-Negative Bacteria in Unipolar Major Depression and Bipolar Disorder Type 1, Especially When Melancholia Is Present. Neurotox Res. 2020;37(2):338-348.
Oxidative stress was measured with the Biomedica oxidized LDL (oxLDL) ELISA
• High specificity to MDA adducts
• Small sample volume – 20 µl / well
• Direct measurement
Also check out our oLAB (Anti-Oxidized LDL Autoantibodies) ELISA
• CE marked – for IVD use in the EU
• Only 2 h 15 min total incubation time
• 2 controls included