Biomedica Immunoassays

big ET for the diagnosis of HFpEF


Renal dysfunction may limit the clinical application of NT-proBNP in the diagnosis of heart failure.

Big ENDOTHELIN is an excellent biomarker candidate for the diagnosis of HFpEF in CKD, independent of GFR as recently discussed in: 

Renal function, N-terminal Pro-B-Type natriuretic peptide, propeptide big-endothelin and patients with heart failure and preserved ejection fraction.

Ingrid Gergei, Bernhard K. Krämer, Hubert Scharnagl, Tatjana Stojakovic, Winfried März. Peptides. 2018 Apr 21. pii: S0196-9781(18)30071-8. Click link for abstract


• NT-proBNP is strongly associated with GFR and shows an exponential negative correlation with GFR decline.

• Big ET-1 is much less affected by GFR decline than NT-proBNP

• A single cut-off point is sufficient in the diagnosis of HFpEF in CKD, independent of GFR

The Biomedica Big Endothelin ELISA Assay is: 

EASY - can be used in every lab
CE registered - for IVD use in EU
GOOD ANALYTE STABILITY in serum and plasma

Related products: 

NT-proBNP ELISA, SK-1204
proANP ELISA, BI-20892
NT-proCNP ELISA, BI-20812
Endostatin ELISA, BI-20742
total sNRP1 ELISA, BI-20409

Biomedica ELISA Service Quotation Form