DKK-1 ELISA - for IVD use in EU
DKK-1 ELISA - now CE marked for IVD use in EU
Dickkopf-1(DKK-1) is a 28.67 kDa secreted protein that acts as soluble inhibitor of the WNT signalling pathway. This pathway contains lipid-modified glycoproteins that activate cell surface receptor-mediated signal transduction to regulate cell activities like: cell fate, proliferation, migration, polarity and gene expression. DKK-1 regulates developmental processes of all kinds. Thus, DKK-1 is also involved in the regulation of bone metabolism as it effects osteoblast differentiation and in regulation of tumourgenetic activity.
Areas of interest: rheumatoid arthritis, oncology, myeloma bone disease, ankylosing spondylitis, glucocorticoid induced osteoporosis, diffuse idiopathic skeletal hyperostosis, monoclonal gammopathy of undetermined significance
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