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Vanin-1 is a marker for the early detection of acute kidney injury
Vanin1 is a glycoprotein which is selectively expressed in renal tubular cells.
Urinary Vanin1 is a biomarker for the prediction of drug induced acute kidney injury. Compared with KIM-1 and NGAL, Vanin-1 has shown superior value in AKI detection. It can also help in the detection and monitoring of obstructive nephropathy.
Vanin-1 is a marker for the early detection of acute kidney injury
At Biomedica, we offer the FIRST fully validated VANIN-1 (urine) ELISA. Our quick, one-step ELISA is optimized for human urine samples and rigorously validated according to FDA/ICH/EMEA guidelines.
Check out the Vanin-1 ELISA validation data
Related literature:
Urinary Vanin-1 As a Novel Biomarker for Early Detection of Drug-Induced Acute Kidney Injury
Hosohata K et al., J Pharmoc Exp Therapeut, 2012
A Novel Biomarker for Acute Kidney Injury, Vanin-1, for Obstructive Nephropathy: A Prospective Cohort Pilot Study
Washino S. et al., Int J Mol Sci, 2019
Abstract
Background: Vanin-1 is a novel acute kidney injury (AKI) biomarker that has not been clinically investigated as a biomarker for obstructive nephropathy. This study investigated the diagnostic value of vanin-1 as a biomarker for adult obstructive nephropathy by comparing it to existing AKI biomarkers. Methods: A total of 49 patients, 21 controls, and 28 hydronephrosis (HN) cases were assessed. AKI biomarkers in bladder (BL) urine and renal pelvic (RP) urine in the HN group were compared to each BL marker in the control group. In a subgroup of cases receiving interventions for obstructive nephropathy, the BL values of each biomarker were assessed after the intervention. Results: RP vanin-1 levels were significantly higher while BL vanin-1 levels were marginally higher in the HN group than in the control group. The area under the receiver operating characteristics curve values for RP and BL vanin-1 were 0.9778 and 0.6386, respectively. In multivariate analyses, BL vanin-1 and N-acetyl-β-D-glucosaminidase (NAG), but not kidney injury molecule-1 (KIM-1) or neutrophil gelatinase-associated lipocalin (NGAL), were independent factors for predicting the presence of HN. In cases receiving interventions, vanin-1 decreased significantly from 1 week after the intervention in cases of moderate to severe obstructive nephropathy compared to RP values at baseline. Conclusion: Urinary vanin-1 is a useful biomarker to detect and monitor the clinical course of obstructive nephropathy.