The infarction zone is the main source of NT-proANP after mycardial infarction
26 January, 2021
Myocardial infarction leads to a an increase in serum levels of ANP (Atrial natriuretic peptide). In a study with a myocardial infarction rat animal model, Zhang et al. showed that the increase in ANP occurs primarily due to an AGTR1/NF-κB mediated upregulation of the ANP gene transcription in the infarcted myocardium. This suggests that specifically the infarcted zone is an important pharmacological target for routine medical heart failure therapies that target AGTR1. https://buff.ly/3ix5tfs
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