Download biomedica product listDelirium is a common and major complication subsequent to cardiac surgery. Despite scientific efforts, there are no parameters which reliably predict postoperative delirium. In delirium pathology, natriuretic peptides (NPs) interfere with the blood–brain barrier and thus promote delirium. A recent study by Saller et al. , which used the Biomedica NT-proCNP ELISA, found a positive correlation between delirium and preoperative plasma levels of ANP and serum levels NT-proCNP. Both ANP and NT-proCNP predicted delirium, but did not correlate with postoperative survival or long-term cognitive decline.
Natriuretic Peptides as a Prognostic Marker for Delirium in Cardiac Surgery-A Pilot Study.
Saller T, et al. Medicina. 2020;56(6):258.
Check out the Biomedica the NT-proCNP ELISA
• CE marked
• Protocols for urine, cell culture and non-human samples
And the NT-proANP ELISA
• CE marked
• Small sample volume – 10 µl / well
• Assay suitable for rat/mouse samples
Sepsis-associated encephalopathy (SAE) has significant impact on the neurocognitive outcome of sepsis survivors. Biomarkers of brain injury and inflammation could help monitor encephalopathy in patients with sepsis.
Levels of NT-proCNP, a protein which is released during systemic inflammation, are highly elevated in both the plasma and CSF of sepsis patients with SAE. Since NT-proCNP levels in CSF and plasma NT-proCNP are highly correlated, plasma NT-proCNP might be a useful proxy biomarker to predict the emergence of SAE during the early phase of sepsis and detect neurological impairment at the later stages of the disease.
Plasma NT-proCNP measurement might be superior to S100B and NSE in SAE.
Ehler et al. Diagnostic value of NT-proCNP compared to NSE and S100B in cerebrospinal fluid and plasma of patients with sepsis-associated encephalopathy. Neurosci Lett. 2019;692:167-173.
For more information on the Biomedica NT-proCNP ELISA check out: https://www.bmgrp.com/product/cardiovascular/biomedica-nt-procnp-elisa/