Plasma levels of Semaphorin 4D are decreased by adjuvant tamoxifen but not aromatase inhibitor therapy in breast cancer patients.
Göbel A. et al., J Bone Oncology, 2019; 16: 100237. Full publication.
SEMAPHORIN 4D is a soluble and membrane-bound protein
that plays important roles in physiologic processes such as vascular growth, tumor progression, and immune cell regulation.
The Role of Semaphorin 4D in Bone Remodeling and Cancer Metastasis.
Lontos K et al., Front Endocrinol, 2018; 9:322. Full publication.
A high-sensitivity enzyme immunoassay for the quantification of soluble human semaphoring 4D in plasma.
Laber A et al., Anal Biochem, 2019; 574:15-22. Full publication.
Did you know?
Soluble Semaphorin 4D can easily be quantified with the Biomedica SEMA4D ELISA
√ HIGHLY SPECIFIC – antibodies bind with high affinities to conformational epitopes in the sema domain
√ ACCURATE – successful validation according to FDA guidelines
√ RELIABLE – 7 human plasma based standards and 2 controls for biologically reliable data
√ LOW SAMPLE VOLUME – only 10 µl / well required
√ Plasma is the suitable matrix for reproducible quantification of sSEMA4D