Neuropilin-1 is a host factor for SARS-CoV-2 infection
Neuropilin-1 (NRP1) is abundantly expressed in the respiratory and olfactory epithelium, with highest expression in endothelial cells and in the epithelial cells facing the nasal cavity. Neuropathological analysis of human COVID-19 autopsies revealed SARS-CoV-2 infected NRP1-positive cells in the olfactory epithelium and bulb. Link to abstract.
NRP1 can reliably be measured by ELISA in human serum, plasma and urine samples with a fully validated assay. Only 10 µl of sample volume is required!
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Find out more: Total Neuropilin-1 ELISA
Neuropilin‑1 as a new potential SARS‑CoV‑2 infection mediator implicated in the neurologic features and central nervous system involvement of COVID‑19 . https://www.spandidos-publications.com/10.3892/mmr.2020.11510.
Neuropilin-1 facilitates SARS-CoV-2 cell entry and provides a possible pathway into the central nervous system. https://www.biorxiv.org/content/10.1101/2020.06.07.137802v1.abstract .