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Lyme Disease Testing
Lyme disease or Lyme Borreliosis is a bacterial infection that is spread to humans by infected ticks (1). It is the most common tick-transmitted infection in temperate zones of the northern hemisphere. Symptoms include fever, headache, fatigue, and an expanding skin rash. If left untreated, the infection can spread to various parts of the body, affecting joint, heart, and the nervous system. Early diagnosis and treatment are essential for effectively managing Lyme Borreliosis. In a recent investigators highlight notable neurological and musculoskeletal complications in patients with Lyme disease, underscoring the critical need for early diagnosis, thorough treatment, and supportive care (2) .
Lyme Disease Testing
BIOMEDICA´s BORRELIA ELISA kits utilize recombinant antigens for the detection of IgG and IgM antibodies against the immunodominent antigens of the three genospecies: Borrelia burgdorferi sensu stricto, Borrelia afzelii and Borrelia garinii
Features include:
- High sensitivity and specificity confirmed by clinical samples
- Use of different immunodominant antigens for the early and late phase
- CE -marked for IVD use in the EU
- For manual and automated testing
- Cited in numerous publications
Example of a Biomedica ELISA Kit
ENZYME-LINKED IMMUNOSORBANT ASSAY FOR THE QUALITATIVE OR QUANTITATIVE DETERMINATION OF IgM ANTIBODIES TO BORRELIA IN PLASMA, SERUM OR CEREBROSPINAL FLUID
Recombinant antigens utilized in the Biomedica Borrelia IgM ELISA Assay:
- p21 OspC – B. afzellii (pKo)
- p21 OspC – B. garinii (20047)
- p41/I – B. bavariensis (pBi)
- VIsE – fusion proteins of different Borrelia genospecies
More information can be found in the protocol booklet here
Borrelia IgG ELISA ▪ BI- 21032
ENZYME-LINKED IMMUNOSORBANT ASSAY FOR THE QUALITATIVE OR QUANTITATIVE DETERMINATION OF IgG ANTIBODIES TO BORRELIA IN PLASMA, SERUM OR CEREBROSPINAL FLUID
Recombinant antigens utilized in the Biomedica Borrelia IgG ELISA Assay:
- p21 – OspC – B. burgdorferi sensu stricto (B31), B. garinii (20047)
- p18 – B. afzelii (pKo)
- p100 – B. afzelii (pKo)
- VIsE – fusion protein of different Borrelia genospecies
More information can be found in the protocol booklet here
Literature
- Lyme Disease. Ann Intern Med. Smith RP. 2025; 178(5):ITC65-ITC80. doi: 10.7326/ANNALS-25-01111. PMID: 40354663.
- Lyme disease associated neurological and musculoskeletal symptoms: A systematic review and meta-analysis. Bushi G, Balaraman AK, Gaidhane S, Ballal S, Kumar S, Bhat M, Sharma S, Kumar MR, Sinha A, Khatib MN, Rai N, Sah S, Yappalparvi A, Samal SK, Lingamaiah D, Shabil M. Brain Behav Immun Health. 2025; 2;43:100931. doi: 10.1016/j.bbih.2024.100931. PMID: 39867846.
- Seroprevalence of Borrelia, Anaplasma, Bartonella, Toxoplasma, Mycoplasma, Yersinia, and Chlamydia in Human Population from Eastern Poland. Wójcik-Fatla, A.; Sawczyn-Domańska, A.; Kloc, A.; Krzowska-Firych, J.; Sroka, J. Pathogens 2025, 14, 96.