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Gut-Heart Axis in Coronary Artery Disease
microbial–metabolic signatures associated with plaque destabilization and resolution
Coronary artery disease (CAD) is the primary cause of death worldwide (1). Clinical manifestations of CAD are divided into chronic or stable CAD (sCAD), characterized by gradual artery narrowing, and acute coronary syndromes (ACS), which involve a sudden interruption of blood flow (2).
The human gut hosts trillions of microbes, known as the gut microbiota, which play key roles in metabolism and immune regulation. Its composition, influenced by environment and genetics, and changes in the gut microbiota have been linked to CAD development. Microbial metabolites can also enter circulation and contribute to CAD pathology (3).
Gut-Heart Axis in Coronary Artery Disease
In a recent study researchers explored the role of the gut-heart axis in coronary artery disease: Distinct microbial and metabolic shifts characterize acute coronary syndrome and recovery. Xu J et al., Imeta. 2025.
Key highlights:
- Changes in the gut microbiome are closely linked to CAD progression.
- Changes are observed across normal coronary arteries, stable CAD, and acute coronary syndrome (ACS).
- Multi-omics machine learning models effectively differentiated CAD subtypes, outperforming traditional clinical risk factors.
Our human NT-proBNP assay was featured in this study.
NT-proBNP ELISA (cat. no. SK-1204)
√ CONVENIENT – can be used in every lab
√ RELIABLE – Full validation package
√ EASY – 5 pre-diluted standards and 2 controls included
√ TRUSTED – Widely cited in more than 140 publications
Literature
- Global prevalence of coronary artery disease: an update from the global burden of disease study. Stark, B, Johnson, C, Roth, G. JACC.2024 Apr, 83 (13_Supplement) 2320.
- Acute and chronic coronary artery disease. Lancellotti P. Acta Cardiol. 2024 Apr;79(2):105-108. PMID: 38628088.
- The role of gut microbiota in cardiovascular diseases and their potential as novel therapeutic targets. Yamashita T. J Cardiol. 2025 Aug;86(2):141-147. doi: 10.1016/j.jjcc.2025.05.002. Epub 2025 May 21. PMID: 40409712.
- Distinct microbial and metabolic shifts characterize acute coronary syndrome and recovery. Xu J et al., Imeta. 2025 Sep 19;4(5):e70079. PMID: 41112052.