FGF23 production is directly regulated by energy intake
Fibroblast growth factor 23 (FGF23) is a bone derived hormone involved in the regulation of phosphate and vitamin D metabolism. FGF23 is increased in patients with renal failure and has been shown to be a risk factor in cardiovascular mortality not only in kidney disease but also in the general population. FGF23 levels are elevated in obese people and increased energy intake is a potential predictor of plasma FGF23 concentrations. In a recent study, three groups of rats were fed diets with high, normal and low caloric content that resulted in different energy intake. The authors could demonstrate that FGF23 production is directly regulated by energy availability.
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