Decline in Kidney function and decreasing NT-proBNP predict outcomes for Acute Decompensated Heart Failure
Acute declines in kidney #function occur in approximately 20%-30% of patients with acute decompensated heart failure, but its significance is unclear, and the importance of its context is not known.
In a study by McCallum et al., a decline in estimated glomerular filtration rate (eGFR), related to worsening kidney function, was not significantly associated with death and rehospitalization of the patient. However, there is a remarkable interaction between decline in eGFR and change in NT-proBNP. When both eGFR and NT-proBNP declined, acute decompensated heart failure patients had significantly better outcomes.
This suggests that including of congestion biomarkers may aid clinical interpretation of eGFR declines.
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