Big Endothelin-1 level is an independent predictor of long-term mortality in patients with three-vessel disease.
Endothelin-1 (ET-1) is a potent vasoconstrictor secreted by vascular endothelial cells. Due to its high biologic activity, ET-1 is rapidly cleared. However, big ET-1, the precursor of ET-1, has a much longer half-life, circulates in higher concentrations and is easier to detect. Thus, big-ET-1 is a more suitable marker and can be used as an alternative approach for the indirect estimation of ET-1 release. Big ET-1 has been implicated in the pathophysiology of numerous cardiovascular diseases.
Did you know?
Big ET can easily be measured using Biomedica’s Big ET ELISA:
√ Direct measurement – highly sensitive
√ CE marked – for IVD use in EU
√ Fully validated according to FDA/ICH/EMEA guidelines
√ Published cut-off values for Three vessel disease (TVD)
Prognostic Value of Plasma Big Endothelin-1 Level Among Patients with Three-Vessel Disease: A Cohort Study. https://doi.org/10.5551/jat.47324.
Association of Baseline Big Endothelin-1 Level With Long-Term Prognosis Among Cardiac Resynchronization Therapy Recipients. https://pubmed.ncbi.nlm.nih.gov/29913121/
The Association between Plasma Big Endothelin-1 Levels at Admission and Long-Term Outcomes in Patients with Atrial Fibrillation.https://doi.org/10.1016/j.atherosclerosis.2018.02.034.
The Value of Big Endothelin-1 in the Assessment of the Severity of Coronary Artery Calcification. https://doi.org/10.1177/1076029618764846.