Altered Concentrations of DKK1 and FGF23 in WNT1 and PLS3 Osteoporosis
Recent advancements in genetic #research have uncovered new forms of monogenic #osteoporosis. Mutations in WNT1, encoding a WNT/β-catenin pathway ligand WNT1, and PLS3, encoding X chromosomally inherited plastin 3 (PLS3), both result in early-onset osteoporosis with prevalent fractures and disrupted bone metabolism.
Data from a study by Mäkitie RE et al. indicate a link between PLS3 and DKK1 and WNT1 and FGF23 in bone metabolism (measured with biomedica kits). Therefore, DKK1 and FGF23 may be clinically useful biomarkers for PLS3 and WNT1 osteoporosis, respectively.
– Reliable – validated according to international guidelines
– Specific – epitope mapped antibodies
– CE marked – widely cited in clinical studies
Biomarkers in WNT1 and PLS3 Osteoporosis: Altered Concentrations of DKK1 and FGF23 . Mäkitie RE et al., J Bone Miner Res, 2020 May;35(5):901-912.